Effects of Wuzhi capsule on blood concentration of tacrolimus after renal transplantation

K Wang; QS. Qu; YX. Zhang; SZ. Miao; X. Jiang

doi:10.54517/jbrha4057

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Effects of Wuzhi capsule on blood concentration of tacrolimus after renal transplantation

K Wang, QS. Qu, YX. Zhang, SZ. Miao, X. Jiang

Article ID: 4057
Vol 30, Issue 1, 2016

DOI: https://doi.org/10.54517/jbrha4057

Received: 8 April 2016; Accepted: 8 April 2016; Available online: 8 April 2016; Issue release: 8 April 2016

Abstract

This study aimed to investigate the effects of Wuzhi capsule on blood concentration of tacrolimus after renal transplantation. Sixty patients after allogenic renal transplantation were enrolled in this study and randomly divided into an experimental group and a control group. One oral Wuzhi capsule was taken in the morning and evening for patients in the experimental group, while none was given to the control group, maintaining the trough blood concentration of tacrolimus in the normal range. After 3 weeks, the changes of tacrolimus dosage and hepatorenal function in the two groups were compared. Comparisons of drug dosage and blood concentration C0 value of tacrolimus before initiating the experiment showed that there was no statistically ignificant difference (P>0.05) between the two groups. The differences of blood concentration of tacrolimus and hepatorenal function for patients in both two groups after 3 weeks treatment also showed no statistical significance (P>0.05), whereas a statistically significant decrease was demonstrated in the tacrolimus dosage of the Wuzhi capsule group compared with that of the control group (P=0.0083). After renal transplantation, Wuzhi capsules were added so as to enable tacrolimus to reach a suitable blood concentration, which can prevent the occurrence of renal transplantation rejection, thus alleviating the economic burden of patients and producing larger social benefits.

Keywords

Wuzhi capsule;renal transplantation;tacrolimus concentration

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