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Mast cell activation and inhibition from cytokines secreted by macrophages
Vol 35, Issue 6, 2021
Abstract
Mast cells (MCs) are ubiquitous immune cells that participate in allergic reactions through the ac- tivation of the FCeRI receptor, but also in inflammatory processes induced by various biological and non-biological compounds, neurotransmitters, and cytokines. Activation of MCs can lead to the immediate release of chemical mediators of inflammation, but it can also result in the secretion of pro-inflammatory cytokines without degranulation. In the inflammatory network, macrophages cross-talk with MCs by producing IL-1, which stimulates MCs to secrete pro-inflammatory cytokines including IL-6, TNF, IL-33 and other cytokines and chemokines. IL-37 and IL-38 are anti-inflammatory cytokines implicated in the suppression of the immune and inflammatory system. Therefore, it is pertinent to think that these cytokines can open new pathways in the field of inflammatory and immune diseases. Here we report the relationships between macrophage cytokines, MCs, and inflammation.
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Copyright (c) 2021 M. Trimarchi, D. Lauritano, G. Ronconi, A. Caraffa, C.E. Gallenga, I. Frydas, S.K. Kritas
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy