Deranged growth factors as a prognosticator of cardiovascular risks in patients with uterine fibroids

S. Bokhari; S. Ahmad; U. Rafi; MA. Iqbal; MA Khan; N. Roohi

doi:10.23812/21-437-A

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

Deranged growth factors as a prognosticator of cardiovascular risks in patients with uterine fibroids

S. Bokhari, S. Ahmad, U. Rafi, MA. Iqbal, MA Khan, N. Roohi

Article ID: 3904
Vol 36, Issue 1, 2022

DOI: https://doi.org/10.23812/21-437-A

Received: 11 March 2022; Accepted: 11 March 2022; Available online: 11 March 2022; Issue release: 11 March 2022

Abstract

Background: Angiogenesis is a crucial factor for the pathogenesis and growth of fibroids. Among various growth factors, transforming growth factor (TGFβ1) and vascular endothelial growth factor (VEGF) are up-regulated in leiomyomas and have angiogenic as well as pro-atherogenic properties. Subsequently, their elevated values may be involved in developing cardiovascular disorders.Objective: The current study was planned to evaluate the role of growth factors in females with uterine fibroids and investigate the future risks of developing cardiovascular disorders (CVD) in these patients.Method: Eighty-two subjects of uterine fibroids and eighty-two healthy controls were selected from tertiary care hospitals. Enzyme-linked immunosorbent assay (ELISA) was utilized to assess growth factors. Results: The levels of TGFβ1 and VEGF were significantly higher (P < 0.001) in patients with uterine fibroids compared to healthy females without uterine fibroids.Conclusion: High level of circulating growth factors in patients with uterine fibroids prognosticate (CVD) events in these patients.

Keywords

VEGF;TGFβ1;Uterine Fibroids;CVD

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Medical Genetics, University of Torino Medical School, Italy

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-01-21

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