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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.
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2025
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Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.
Obesity Factors in Failure Analysis of Cemented Total Hip Replacement
Article ID: 3511
Vol 39, Issue 1, 2025
DOI: https://doi.org/10.23812/j.biol.regul.homeost.agents.20253901.12
Vol 39, Issue 1, 2025
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Abstract
Background: This article mainly analyzed the influence of obesity constitution on the failure of cemented total hip replacement.
Methods: By collecting body mass index (BMI) data of patients with hip joint and bone mineral density (BMD) of femur, the age,
gender and number of patients were statistically analyzed, and the influence of body weight on postoperative implant force was
analyzed by finite element method modeling analysis.
Results: Studies have found that obesity and BMI reaching overweight or obesity standards will aggravate the symptoms of hip
patients, and the effects will be different between different genders. The effects of body weight on hip replacement, fracture of
bone cement stem, sinking of prosthesis stem and loosening of bone cement-stem interface were analyzed in detail.
Conclusions: It was proved that BMI had a great correlation with postoperative failure. In addition, the effect of weight loss
drugs on postoperative rehabilitation immune system was discussed.
Keywords
obesity; failure; total hip replacement; immune system
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Copyright (c) 2025 Lanfeng Zhang,Hongtao Liu,Feng Yuan,Tianchi Chen,Lin Xu,Jingmao Wang, Yancheng Wang,Ziyue Tong
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Editor-in-Chief
Medical Genetics, University of Torino Medical School, Italy
Co-Editor-in-Chief
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy
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News & Announcements
2025-02-01
In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.
2025-01-21
Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.