Background: Existing research has found that the Spike 2 protein of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is homogenous to the gp41 protein of the Human Immunodeficiency Virus-1. Postmortem SARS-CoV-2 patients are reported to exhibit microglial activation and expression of interleukin (IL)-1β and IL-6, corroborating with the other in vitro observations. Methods: The translational research draws upon the phenomena from metacognition in dreams to achieve the therapeutic solution conception on Coronavirus Disease 2019 (COVID-19) vaccination-induced central nervous system (CNS) cytokine expression. Results: Partial milestones have been achieved with cognitive-behavioral therapy in combination with agomelatine and γ-aminobutyric acid stimulation physical therapy, and the direct evidence suggests that the temporal amelioration was contributed by interleukin 6 inhibition with Agomelatine’s mechanism of action. The photic and nonphotic treatment designs have progressed in the clinical trials by the evidence-based medicine method. Conclusions: The conservation of the circadian CNS function is the main direction for the purpose of the study design progress, and the case study for the participant with Asperger’s Syndrome indicates the correlation of migraine in autism spectrum disorder with interferon-λ.

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