Aim: The utility of the ^99mTc-sestamibi myocardial perfusion stress imaging (MPI) over stress echo test (SEHO) in women with intermediate pre-test probability scores. Methodology: Our study included 98 women with suspected ischemic heart disease and intermediate pre-test probability scores who underwent MPI and SEHO. They were followed for 26 ± 6 months. The data about MACE and possible coronary angiography were collected. Results: The SEHO test was pathological in 31% of the study population. Almost half of those patients had atypical chest pain. MPI was positive in 32% of the examined group. In the follow-up period, MACE was present in 36 patients: PCI (20), CABG (8), acute coronary syndrome (8). The results of the MPI had a high statistically significant correlation with the coronary angiography findings in the follow-up period (p < 0.001, μ = 0.878). Additionally, the SEHO test and coronary angiography results correlated well (p < 0.05, μ = 0.582). However, MPI test result and SEHO result were not significantly associated with MACE based on Cox proportional hazard analyses (p > 0.05). Conclusion: MPI may be the complementary procedure for the evaluation of heart conditions in women with intermediatepre-test probability scores, since it correlates well with coronary angiography findings.