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Effects of obstructive sleep apnea on cardiac autonomic nervous homeostasis
Vol 4, Issue 2, 2023
Issue release: 31 December 2023
VIEWS - 1996 (Abstract)
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Abstract
Objective: To investigate the effect of obstructive sleep apnea hypopnea syndrome (OSAHS) on cardiac autonomic nervous homeostasis. Methods the patients with OSAHS diagnosed in our hospital were the observation group, and the non OSAHS patients in the same period were the control group. The differences of baseline data, sleep monitoring, time domain analysis index of heart rate variability, peripheral blood methoxyepinephrine (MN) and methoxynorepinephrine (NMN) between the two groups were analyzed. The observation group was divided into light, medium and heavy groups according to apnea index (AHI), and the correlation analysis between age, AHI, lsao2, time domain index and blood catecholamine metabolites was carried out. Results: Ahi was negatively correlated with SDNN and PNN50% (P <0.01) and positively correlated with NMN (p<0.05); lsao2 was positively correlated with SDNN and PNN50% (P <0.05), and negatively correlated with vanillic acid 2 (p<0.05). Conclusion patients with OSAHS have obvious disturbance of cardiac sympathetic and vagus nerve balance at night.
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References
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Prof. Prakash Deedwania
University of California,
San Francisco, United States
