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Research progress and controversy on T wave formation mechanism
Vol 2, Issue 2, 2021
Issue release: 31 December 2021
VIEWS - 4611 (Abstract)
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Abstract
Although ECG has been developed for a hundred years, the mechanism of T wave formation is unknown. The proposal of in vitro wedge-shaped model has greatly promoted the understanding of T-wave formation mechanism. By comparing the action potentials of epicardial cells, medial cells and endocardial cells in wedge-shaped ventricular mass with the T wave of body surface ECG, it was found that the T wave was mainly formed by the dispersion of transmural repolarization of ventricular muscle. However, in the subsequent in vivo experiments, electrophysiologists found that the formation of T wave was related to the dispersion of ventricular global repolarization, and the repolarization order of different parts of the three-dimensional global heart determined the polarity of T wave. In the real heart, the mechanism of T wave formation may be more complex, its repolarization gradient may include repolarization in each axis of the heart, and the polarity of T wave may also be the result of multiple factors.
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References
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Prof. Prakash Deedwania
University of California,
San Francisco, United States
