Construction of logic gates and semi adders for simultaneous detection of two DNA molecules
Vol 2, Issue 1, 2021
VIEWS - 38 (Abstract)
Abstract
In this study, graphene oxide/gold nanoparticles composite membrane modified electrodes (gce/go/aunps) were constructed by drop coating and electrodeposition. Based on the change of the probe's surface configuration before and after the combination of the target DNA and the probe, the electrochemical signal changes, so as to realize the intelligent recognition of E.coli DNA and Salmonella DNA. Take the target as the input signal, and Σ|ΔI| and |ΔIMB/ΔIFC| constructs "and" and "XOR" DNA molecular logic gates for output, and proposes a new semi adder model that can be used for logic operations. Square wave voltammetry (SWV) was used to detect the current change value Σ|ΔI| of the two labeled probes, which was consistent with E. The logarithmic values of the concentrations of coli DNA and Sal DNA showed a good linear relationship in the range of 1.0 × 10–13 to 1.0 × 10–8 mol·L–1, and the detection limits (S/N = 3) were respectively 3.2×10–14 mol·L–1 and 1.7×10–14 mol·L–1.
Keywords
Full Text:
PDFReferences
1. Feynman R P.Reinhold, 1961, (2):282.
2. Adlemanlm.Science, 1994, 266(5187):1021.
3. Chen J, Zeng L.Biosensors and Bioelectronics, 2013, 42:93.
4. Wu C, Wan S, Hou W, et al.Chemical Communication, 2015, 51(18):3723.
5. FAN C H, LIU D S.DNA Nanotechnology.Beijing:Science Press, 2011:409.
6. Li W, Zhang F, Yan H, et al.Nanoscale, 2016, 128(8):3775.
7. Robinson J T, Perkins F K, Snow E S, et al.Nano Letters, 2008, 8(10):3137.
8. Wang Z, Zhou X, Zhang J, et al.The Journal of Physical Chemistry C, 2009, 113(32):14071.
9. Liu X, Aizen R, Freeman R, et al.ACS Nano, 2012, 6(4):3553.
10. FU L, LIU H B, ZOU Y H, et al.Carbon, 2005, 33(4):10.
Refbacks
- There are currently no refbacks.
