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Exploring the Significance of SOAT1/ACAT1 in Cancer Pathogenesis
Vol 38, Issue 1, 2024
Abstract
Sterol O-acyltransferase 1 (SOAT1), also known as Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1), belongs to the membrane-bound O-acyltransferase enzyme family and plays a crucial role in maintaining intracellular cholesterol homeostasis. Numerous studies have documented the association between aberrant SOAT1 expression and various aspects of cancer biology, including cell proliferation, apoptosis, invasion, and metastasis. In this comprehensive review, we outline the multifaceted role of SOAT1 in tumor initiation, progression, and therapeutic responses. Furthermore, we elucidate its potential as a prognostic marker and highlight its clinical relevance as a promising therapeutic target for malignancies.
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Supporting Agencies
Copyright (c) 2024 Dan Cao, Da-Chen Luo, Li Jiang
This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy