Renal lithiasis in children

Gloriana Chacón-Retana, Sara Fernández-Rojas

Article ID: 2122
Vol 3, Issue 2, 2022

VIEWS - 54 (Abstract)

Abstract

Justification and objective: Renal lithiasis is due to the precipitation of crystals due to an imbalance in the urine between promoting substances and inhibitory substances. It is a pathology with a prevalence between 2–10% in the pediatric population, with an incidence that has increased in the last 25 years; for this reason this study aims to know the prevalence, clinical and metabolic manifestations of renal lithiasis in the pediatric population of the National Children's Hospital of Costa Rica. Methods: Tthis is a retrospective, descriptive and observational study, through the review of records of patients under 18 years of age with the diagnosis of renal lithiasis, attended at the National Children's Hospital, in the period from January 2000 to 2018. Results: A total of 106 patients were included. The average age at diagnosis was 6.6 ± 3.8 years; the frequency of cases has increased 5.5 times in the last 5 years. Risk factors detected: urinary tract abnormalities 22.6% and family history of lithiasis 17.9%. Metabolic analysis showed low urine output in 74.3%, hyperphosphaturia in 43.2%, hypomagnesuria 39.2% and hypercalciuria 37.8%. Etiologies determined: metabolic 54.7%, urinary tract malformations 16% and idiopathic in 30.9%. Intracorporeal lithotripsy was applied in 61.2%. Recurrence was observed in 28.5% of cases, and a relationship was found between the incidence of recurrence and the size of the lithotripsy (p = 0.001) and surgical treatment (p = 0.010). Conclusions: There is an increase in the frequency of cases of pediatric lithiasis with a multifactorial etiology at the National Children's Hospital of Costa Rica.


Keywords

nephrolithiasis; urinary tract, hypercalciuria; lithotripsy; metabolic

Full Text:

XML



References

1. Marra G, Taroni F, Berrettini A, Montanari E, Man-zoni G, Montini G. Pediatric nephrolithiasis: a sys-tematic approach from diagnosis to treatment. J Nephrol. 2019; 32:199–210

2. Shoag J, Tasian G, Goldfarb D, Eisner B. The new epidemiology of nephrolithiasis. Adv Chronic Kidney Dis. 2015; 22:273–278.

3. Rodrigo M, Vicente C. Renal lithiasis and idiopathic hypercalciuria. Protoc diagn ter pediatr. 2014; 1:155–170.

4. Bowen D, Tasian G. Pediatric stone disease. Urol Clin A Am. 2018; 45: 539–550.

5. Marzuillo P, Guarino S, Apicella A, La Manna A, Polito C. Why we need a higher suspicion index of urolithiasis in children. J Pediatr Urol. 2017; 13:164–171

6. Sighinolfi M, Eissa A, Bevilacquia L, Zoeir A, Ciarlariello S, Morini E, et al. Drug-Induced uro-lithiasis in pediatric patients, Pediatr Drugs. 2019; 21:323–344.

7. Sas DJ, Becton L, Tutman J, Lindsay L, Wahlquist A. Clinical, demographic, and laboratory charac-teristics of children with nephrolithiasis, Urolithia-sis. 2016; 44: 241–246

8. Issler N, Dufek S, Kleta R, Bockenhauer, Smeulders N, Van't Hoff W. Epidemiology of paediatric renal stone disease: a 22 year single centre experience in the UJ. BMC Nephrol. 2017; 18:136–143.

9. De Ruysscher C, Pien L, Tailly T, Van Laecke E, Vande J, Prytula A. Risk factors for recurrent uro-lithiasis in children. J Pediatr Urol. 2019; 16:1–29.

10. VanDervoort K, Wiesen J, Frank R, Vento S, Crosby V, Chandra M, et al. Urolithiasis in pediatric pa-tients: a single center study of incidence, clinical presentation and outcome. J Urol. 2007; 177:2300–2305.

11. Sarkissian A, Babloyan A, Arikyants N, Hesse A, Blau N, Leumann E. Pediatric urolithiasis in Arme-nia: a study of 198 patients observed from 1991 to 1999. Pediatr Nephrol. 2001; 16:728–732.

12. Hernandez J, Ellison J, Lendvay T. Current trends, evaluation, and management of pediatric nephro-lithiasis. JAMA Pediatr. 2015; 169:964–970.

13. Yang D, Tiselius H, Lan C, Chen D, Chen K, Ou L, et al. Metabolic disturbances in Chinese children with urolithiasis: a single center report. Urolithiasis. 2017; 45:285–290.

14. Scoffone C, Cracco C. Pediatric calculi: cause, prevention and medical management. Curr Opin Urol. 2018; 28:428–432.

15. Matlaga B, Schaeffer A, Novak T, Trock B. Epide-miologic insights into pediatric kidney stone dis-ease. Urol Res. 2010; 38:453–457.

16. Imran K, Zafar M, Ozair U, Khan S, Rizvi S. Meta-bolic risk factors in pediatric stone formers: a report from an emerging economy. Urolithiasis. 2017; 45:379–386.

17. Velásquez-Forero F, Esparza M, Salas A, Medeiros M, Toussaint G, Llach F. Risk factors evaluation for urolithiasis among children. Bol Med Hosp Infant Mex. 2016; 73:228–236.

18. Bush N, Xu L, Brown B, Holzer M, Gingrich A, Schuler B, et al. Hospitalizations for pediatric stone disease in United States, 2002–2007. J Urol. 2010; 183:1151–1156.

19. Routh C, Graham D, Nelson C. Epidemiological trends in pediatric urolithiasis at United States freestanding pediatric hospitals. J Urol. 2010; 184:1100–1104.

20. Ward J, Feinstein L, Pierce C, Lim J, Abbott K, Bavendam T, et al. Pediatric urinary stone disease inthe United States: The Urological diseases in American project. Urology. 2019; 129:180–187.

21. Dwyer M, Krambeck A, Bergstralh E, Milliner D, Lieske J, Rule A. Temporal trends in incidence of kidney stones among children: a 25 year popula-tion based study. J Urol. 2012; 188:247–252.

22. Edvardsson V, Ingvarsdottir S, Palsson R, Indrida-son O. Incidence of kidney stone disease in Ice-landic children and adolescents from 1985 to 2013: results of a nationwide study. Pediatr Nephrol. 2018; 33:375–1384.

23. Elmaci A, Ece A, Akin F. Pediatric urolithiasis: metabolic risk factors and follow up results in a Turkish region with endemic stone disease. Uro-lithiasis. 2014; 42:421–426.

24. Mai Z, Liu Y, Wu W, Aierken A, Jiang C, Batur J, et al. Prevalence of urolithiasis among the Uyghur children of China: a populationbased cross-sectional study. BJU Int. 2019; 124:395–400.

25. Ece A, Ozdemir E, Gürkan F, Dokucu A, Akdeniz O. Characteristics of pediatric urolithiasis in south-east Anatolia. Int J Urol. 2000; 7:330–334.

26. Mayans L. Nephrolithiasis. Prim Care. 2019; 46:203–212.

27. McKay C. Renal Stone disease. Pediatr Rev. 2010; 31:179–188.

28. Susaeta R, Benavente D, Marchant F, Gana R. Di-agnosis and management of renal lithiasis in adults and children. Clinicas Las Condes Medical Journal. 2018; 29:197–212

29. Cassim R, Van Walraven C, Lavallée L, McAlpine K, Highmore K, Leonard M, et al. Systematic radi-ologic detection of kidney stones in Canadian children: a new era of asymptomatic stones? J Pe-diatr Urol. 2019; 15:467.e1–467.e7

30. Roberson N, Dillman J, O'Hara S, DeFoor W, Reddy P, Giordano R, et al. Comparison of ultrasound versus computed tomography for the detection of kidney stones in the pediatric population: a clini-cal effectiveness study. Pediatr Radiol. 2018; 48:962–972.

31. Van J, Tasian G. Clinical effectiveness in the diag-nosis and acute management of pediatric nephro-lithiasis. Int J Surg. 2016; 36:698704.

32. Colleran G, Callahan M, Paltiel H, Nelson C, Ci-lento B, Baum M, et al. Imaging in the diagnosis of pediatric urolithiasis. Pediatr Radiol. 2017; 47:5–16.

33. Bhat D, Shankar R, Shenoy R, Rai S. Cystine uro-lithiasis in early childhood. Indian J Clin Biochem. 2019; 34:361–362.

34. Bevill M, Kattula A, Cooper C, Storm D. The mod-ern metabolic stone evaluation in children. Urology. 2017; 101:15–20.

35. Rodriguez C, Wang P, Freundlich M, Filler G. Edu-cational review: roleofthepediatricnephrolo-gistsinthework-upandmanagement of kidney stones. Pediatr Nephrol. 2020; 35:383–397.

36. Wumaner A, Keremu A, Wumaier D, Wang Q. High incidence of urinary stones in Uyghur children may be related to local environmental factors. J Pe-diatr Urol. 2014; 10:289–93.

37. Murphy M, Erpelding S, Chishti A, Dugan A, Ziada A, Kiessling S. Influence of BMI in nephrolithiasis in an Appalachian pediatric population: A sin-gle-center experience. J Pediatr Urol. 2018; 14:330. e1–330.e8.

38. García-Perdomo H, Benavidez P, Posada P. Patho-physiology associated with urinary tract stone for-mation. Urol Colom. 2016; 25:109117

39. Goretti M, Saggie U. Managementofpediatricpri-mary urolithiasis. Arch Latin Nefr Ped, 2019; 19: 3–22.


DOI: https://doi.org/10.54517/urr.v3i2.2122
(54 Abstract Views, 0 XML Downloads)

Refbacks

  • There are currently no refbacks.