Open Journal Systems

Research progress on the relationship between fibroblast growth factor 23 and chronic kidney disease

Bingqing Liao, Xinwu Liu, Chengbo Zhao, Runxiu Wang

Article ID: 2100
Vol 4, Issue 1, 2023

DOI: https://doi.org/10.54517/urr.v2i2.2100
VIEWS - 41 (Abstract)

Abstract

Chronic kidney disease(CKD)is now a global public health problem. In chronic kidney disease(CKD)patients，almost all have complications such as calcium and phosphorus metabolism disorders，hyperparathyroidism，cardiovascular disease，anemia，and inflammation，which seriously affect the progress and prognosis of CKD. Fibroblast growth factor 23(FGF23) is a bone-derived hormone that regulates the metabolism of phosphate and vitamin D. In the past，FGF23 was generally considered to play only an important role in the regulation of calcium and phosphorus metabolism. In recent years FGF23has been found to be associated with the occurrence or progression of various CKD complications. This opens up new horizons for studying the role of FGF23 in the course of chronic kidney disease. FGF23 is expected to become a new therapeutic target in the future，improving the prognosis of patients with CKD. This article will review the biological characteristics of FGF23 and its role in the progression of CKD. And briefly discuss its potential future role in chronic kidney disease.

Keywords

fibroblast growth factors; renal insufficiency; nephrology; phosphorus metabolism disorders; cardiovascular diseases

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