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Effect of T3 on the expression of TGF-β1 in the mice diabetic kidney

Yan Meng, He Tian, Ping Zhang

Article ID: 2095
Vol 2, Issue 2, 2021

DOI: https://doi.org/10.54517/urr.v2i2.2095
VIEWS - 40 (Abstract)

Abstract

Objective To observe the effect of triiodothyronine (T3) on the expression of transforming growth factor-β₁ (TGF-β₁), in order to investigate the mechanism of T3 in renal fibrosis. Methods Thirty-six C57/B6 mice were used in this study. The control group (C) included 12 mice, and the others were used to establish diabetic models by injection of streptozotocin (STZ). Then the mice were randomly divided into the diabetes group (DM) and T3 group (T3). The mice were raised for six months. The expression of TGF-β₁ was detected by immunohistochemical stainning, image analysis and Western blot. Results Compared with the control group, the expression of TGF-β₁ was obvi-ously increased in the diabetes group, and the expression of TGF-β₁ in the T3 group was obviously lower than that in the diabetes group. Conclusion T3 reduces the range and process of fibrosis in dia-betic nephropathy by down-regulating expressions of TGF-β₁.

Keywords

T3; diabetes mellitus; kidney; TGF-β1

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