Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.
Renal clear cell sarcoma in the pediatric age: differential diagnosis and management
Vol 4, Issue 2, 2023
VIEWS - 2128 (Abstract)
Download PDF
Abstract
Renal clear cell sarcoma is the second most frequent malignant renal tumor in pediatric age, after Wilms' tumor. It is a difficult to diagnose neoplasm, with nonspecific clinical presentation as palpable abdominal mass, abdominal pain and hypertension and hematuria. The imaging characteristics of this lesion are non-specific, so its diagnosis is made by anatomopathological study of the tumor. Its importance revolves around the diagnostic difficulty, since this tumor presents great histologic variability and few adequate immunohistochemical markers. Treatment includes neoadjuvant and post-surgical chemotherapy, with a prognosis that improves if the disease is diagnosed early.
Keywords
References
1. Brok J, Treger TD, Gooskens SL, van den Heuvel-Eibrink MM, Pritchard-Jones K. Biology and treatment of renal tumours in childhood. Eur J Cancer [Internet]. 2016;68:179-95. https://doi.org/10.1016/j.ejca.2016.09.005
2. Chong WC, Cain JE. Lessons learned from the developmental origins of childhood renal cancer. Anat Rec. 2019;(March):1-17.
3. Walke VA, Shende NY, Kumbhalkar DT. Renal clear cell sarcoma - Anaplastic variant: A rare entity. J Clin Diagnostic Res. 2017;11(1):ED10-1. https://doi.org/10.7860/JCDR/2017/23138.9214
4. Aw SJ, Chang KTE. Clear cell sarcoma of the kidney. Arch Pathol Lab Med. 2019;143(8):1022-6. https://doi.org/10.5858/arpa.2018-0045-RS.
5. Astolfi A, Melchionda F, Perotti D, Fois M, Indio V, Urbini M, et al. Whole transcriptome sequencing identifies BCOR internal tandem duplication as a common feature of clear cell sarcoma of the kidney. Oncotarget. 2015;6(38):40934-9. https://doi.org/10.18632/oncotarget.5882
6. Gooskens SL, Gadd S, Guidry Auvil JM, Gerhard DS, Khan J, Patidar R, et al. TCF21 hypermethylation in genetically quiescent clear cell sarcoma of the kidney. Oncotarget. 2015;6(18):15828-41. https://doi.org/10.18632/oncotarget.4682
7. Chung EM, Graeber AR, Conran RM. Renal tumors of childhood: Radiologic-pathologic correlation part 1. the 1st decade. Radiographics. 2016;36(2):499-522. https://doi.org/10.1148/rg.2016150230
8. Özdemir ZC. Renal clear cell sarcoma presenting as a spontaneously renal hematoma: A rare presentation. North Clin Istanbul. 2017;5(1):60-3. https://doi.org/10.14744/nci.2017.75537
9. Zekri W, Yehia D, Elshafie MM, Zaghloul MS, El-Kinaai N, Taha H, et al. Bilateral clear cell sarcoma of the kidney. J Egypt Natl Canc Inst [Internet]. 2015;27(2):97-100. https://doi.org/10.1016/j.jnci.2015.03.002
10. Gooskens SL, Graf N, Furtwängler R, Spreafico F, Bergeron C, Ramirez-Villar GL, et al. Rationale for the treatment of children with CCSK in the UMBRELLA SIOP-RTSG 2016 protocol. Nat Rev Urol [Internet]. 2018;15(5):309-19. https://doi.org/10.1038/nrurol.2018.14
11. Vokuhl C. Rare childhood kidney tumors. Pathologe. 2019;40(6):600-8.https://doi.org/10.1007/s00292-019-0638-8
12. Koshinaga T, Takimoto T, Oue T, Okita H, Tanaka Y, Nozaki M, et al. Outcome of renal tumors registered in Japan Wilms Tumor Study-2 (JWiTS-2): A report from the Japan Children's Cancer Group (JCCG). Pediatr Blood Cancer. 2018;65(7):1-8. https://doi.org/10.1002/pbc.27056
13. Lang A, Dehner LP. Delayed Metastasis of Clear Cell Sarcoma of Kidney to Bladder After 7 Disease- Free Years. Fetal Pediatr Pathol [Internet]. 2018;37(2):126-33. https://doi.org/10.1080/15513815.2018.1435757
14. Roy A, Kumar V, Zorman B, Fang E, Haines KM, Doddapaneni HV, et al. Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney. Nat Commun [Internet]. 2015;6:1-7. https://doi.org/10.1038/ncomms9891
15. Naous R. TLE1 Positive Clear Cell Sarcoma of the Kidney: A Case Report and Review of the Literature. Case Rep Pathol. 2018;2018(Figure 3):1-5. https://doi.org/10.1155/2018/3462096
Refbacks
- There are currently no refbacks.
Copyright (c) 2023 María José Morales López, Mary Paz Vargas Hernández, Lisa Miranda Solís
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
.png)
Prof. Wei-Yen Hsu
National Chung Cheng University, Taiwan
