Optimization of antibiotic drug regimens to patients with renal dysfunction based on endogenous CLcr and commenting on its rationality

Abstract

Objective: To optimize the antibiotic drug regimens to patients with renal dysfun-ction based on endogenous creatinine clearance(CLcr) and to comment on its rationality. Methods: Rationality and optimizability of the antimicrobial regimens in a medical record were disscussed via the renal function based on CLcr. The original regimens which were considered to be optimized were adjusted via the renal function based on CLcr, When these adjusted regimens achieved the preset threshold of the PK/PD target index which was used to predict the efficacy of regimens, they were considered to be feasible. Results: In the elected medical record, it was found that the dosage of the original regimens was too high or the interval of administration was too short, which indicated that the original regimens could be optimized. The optimized regimens, obtained by adjustment on the original regimens via the renal function based on CLcr and according to the preset threshold of the PK/PD target index, were theoretically not only effective but also more secure. Conclusion: Based on the renal function status reflected by CLcr, the optimization and commenting of antimicrobial drug administration plan and its rationality are helpful for the development of safe, effective and reasonable individualized treatment plan for patients with renal insufficiency complicated with infection; it can serve as the theoretical guidance in clinical practice.