This study examines the role of eco-centric zoning laws and wildlife preservation in mitigating zoonotic spillover, a critical factor in preventing future pandemics. Existing literature establishes a strong correlation between habitat disruption, deforestation, urbanization, and the increasing frequency of zoonotic disease transmission, with cases such as COVID-19, Ebola, and Nipah virus outbreaks underscoring the urgency of intervention. While international and national legal frameworks, including the Convention on Biological Diversity, CITES, and various environmental laws, aim to regulate habitat conservation, gaps persist in their implementation, particularly regarding eco-centric zoning policies. This research addresses these gaps by investigating how legal and policy frameworks can effectively integrate eco-centric zoning and wildlife preservation to reduce the risk of zoonotic spillover. Employing a multidisciplinary approach, the study conducts a comprehensive review of legal precedents, environmental policies, and scientific literature to assess current regulatory measures and propose strategic enhancements. The findings reveal that eco-centric zoning mitigates habitat fragmentation, strengthens biosafety regulations in wildlife facilities, and enhances global surveillance of zoonotic pathogens. Legal tools such as citizen suits, conservation easements, the regulatory takings doctrine, intergovernmental MOUs, and adaptive management emerge as crucial mechanisms for enforcing eco-centric zoning policies. Case studies, such as Bangladesh’s infrastructure-induced elephant fatalities, demonstrate the legal and enforcement challenges surrounding conservation policies. The study argues for the adoption of stricter zoning regulations, increased public participation, the integration of technological solutions for habitat monitoring, and enhanced legal accountability for environmental degradation. By emphasizing the One Health framework, which underscores the interconnectedness of human, animal, and environmental health, the research provides actionable policy recommendations to align conservation efforts with public health strategies. The study’s findings contribute to the advancement of sustainable land-use policies, improved legal mechanisms for biodiversity protection, and a holistic approach to pandemic prevention. In advocating for stronger regulatory frameworks and cross-border legal cooperation, this research underscores the need for a proactive, interdisciplinary response to emerging zoonotic threats.

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